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ความเชี่ยวชาญ

-  Organics Chemistry & Natural Products

- Biological activity testing

- Drugs Discovery

- Cell culture for anti-aging and anti-neuron...

ผลงานวิจัย / ผลงานวิชาการ

Publications

- Sanguanphun, T.; Promtang, S.; Sornkaew, N.; Niamnont, N.; Sobhon, P.; Meemon, K. (2023). Anti-Parkinson Effects of Holothuria leucospilota-Derived Palmitic Acid in Caenorhabditis elegans Model of Parkinson’s Disease. Mar. Drugs, 21, 141.

- Chalorak, P., Sornkaew, N., Manohong, P., Niamnont, N., Malaiwong, N., Limboonreung, T., ... & Meemon, K. (2023). Corrigendum to “Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection from α-synuclein-mediated neurodegeneration in C. elegans model”[J. Ethnopharmacol. 279 (2021) 114347]. Journal of ethnopharmacology, 301, 115844.

- Santiwat, T., Sornkaew, N., Srikittiwanna, K., Sukwattanasinitt, M., & Niamnont, N. (2023). Electrospun nanofiber sheets mixed with a novel triphenylamine-pyrenyl salicylic acid fluorophore for the selective detection of picric acid. Journal of Photochemistry and Photobiology A: Chemistry, 434, 114258.

- Pattarachotanant, N., Sornkaew, N., Warayanon, W., Rangsinth, P., Sillapachaiyaporn, C., Vongthip, W., ... & Tencomnao, T. (2022). Short Lecture “Aquilaria crassna leaf extract attenuates high glucose-induced neurotoxicity and Caenorhabditis elegans lifespan/healthspan reduction”. Planta Medica, 88 (15), SL-D03

- Sanguanphun, T., Sornkaew, N., Malaiwong, N., Chalorak, P., Jattujan, P., Niamnont, N., ... & Meemon, K. (2022). Neuroprotective effects of a medium chain fatty acid, decanoic acid, isolated from H. leucospilota against Parkinsonism in C. elegans PD model. Frontiers in Pharmacology, 13, 1004568.

- Pattarachotanant, N., Sornkaew, N., Warayanon, W., Rangsinth, P., Sillapachaiyaporn, C., Vongthip, W., ... & Tencomnao, T. (2022). Aquilaria crassna Leaf Extract Ameliorates Glucose-Induced Neurotoxicity In Vitro and Improves Lifespan in Caenorhabditis elegans. Nutrients, 14(17), 3668.

- Sangpairoj, K., Settacomkul, R., Siangcham, T., Meemon, K., Niamnont, N., Sornkaew, N., ... & Vivithanaporn, P. (2022). The Extract of Halymenia durvillei Induces Apoptotic and Autophagic Death of Human Triple-negative Breast Cancer Cells by Upregulating ER Stress. Asian Medical Journal and Alternative Medicine, 22, S99-S99.

- Lin, Y., Wongkrajang, K., Shen, X., Wang, P., Zhou, Z., Chuprajob, T., Sornkaew, N., …& Wang, F. (2022). Discovery of Diarylheptanoids that Activate Α7 nAchR-JAK2-STAT3 Signaling in Macrophages with Anti-Inflammatory Activity in Vitro and in Vivo. Bioorganic & Medicinal Chemistry, 116811.

- Sangpairoj, K., Settacomkul, R., Siangcham, T., Meemon, K., Niamnont, N., Sornkaew, N., ... & Vivithanaporn, P. (2022). Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress. Asian Pacific Journal of Tropical Biomedicine, 12(3), 132.

- Santiwat T., Sornkaew N., Mayurachayakul P., Srikittiwanna K., Pratumyot K., Sukwattanasinitt N. Niamnont N. (2022). A new triphenylamine-pyrenyl salicylic acid fluorophore for highly selective Cu(II) ion detection in aqueous media at the picomolar level. Journal of Molecular Structure. 1259, 132735.

- Chalorak, P., Sornkaew, N., Manohong, P., Niamnont, N., Malaiwong, N., Limboonreung, T., ... & Meemon, K. (2021). Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model. Journal of Ethnopharmacology, 279, 114347.

- Tangrodchanapong, T., Sornkaew, N., Yurasakpong, L., Niamnont, N., Nantasenamat, C., Sobhon, P., & Meemon, K. (2021). Beneficial Effects of Cyclic Ether 2-Butoxytetrahydrofuran from Sea Cucumber Holothuria scabra against Aβ Aggregate πToxicity in Transgenic Caenorhabditis elegans and Potential Chemical Interaction. Molecules. 26(8), 2195.

- Manohong, P., Sornkaew, N., Meemon, K., Chompoochai, K., Sobhon, P., Tamtin, M., Sichaem, J., Mingvanish, W., Srisuwannaket, C., Mingvanish, W., & N. Niamnon. (2021). Isolation of 3-(Hydroxyacetyl) indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei: Their Anti-lung Cancer Cell and in vivo Anti-aging Activity. Asian Journal of Chemistry. 33(4).

- Sutjarit, N., Sueajai, J., Boonmuen, N., Sornkaew, N., Suksamrarn, A., Tuchinda, P., ... & Piyachaturawat, P. (2018). Curcuma comosa reduces visceral adipose tissue and improves dyslipidemia in ovariectomized rats. Journal of ethnopharmacology, 215, 167-175.

- Srivilai, J., Rabgay, K., Khorana, N., Waranuch, N., Nuengchamnong, N., Wisuitiprot, W., Chuprajob, T., Changtam, C., Suksamrarn, A., Chavasiri, W., Sornkaew, N., & Ingkaninan, K. (2017). Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors. Medicinal Chemistry Research. 26, 1550-1556.

- Tipbunjong, C., Kitiyanant, Y., Chaturapanich, G., Sornkaew, N., Suksamrarn, A., Kitiyanant, N., ... & Pholpramool, C. (2017). Natural diarylheptanoid compounds from Curcuma comosa Roxb. promote differentiation of mouse myoblasts C2C12 cells selectively via ER alpha receptors. Medicinal Chemistry Research, 26(1), 274-286.

- Chawalitpong, S., Sornkaew, N., Suksamrarn, A., & Palaga, T. (2016). Diarylheptanoid from Curcuma comosa Roxb. suppresses RANKL-induced osteoclast differentiation by decreasing NFATc1 and c-Fos expression via MAPK pathway. European Journal of Pharmacology, 788, 351-359.

- Sornkaew, N., Lin, Y., Wang, F., Zhang, G., Chokchaisiri, R., Zhang, A., ... & Suksamrarn, A. (2015). Diarylheptanoids of Curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 cells. Natural product communications, 10(1), 1934578X1501000123.

- Chuprajob, T., Changtam, C., Chokchaisiri, R., Chunglok, W., Sornkaew, N., & Suksamrarn, A. (2014). Synthesis, cytotoxicity against human oral cancer KB cells and structure–activity relationship studies of trienone analogues of curcuminoids. Bioorganic & Medicinal Chemistry Letters, 24(13), 2839-2844.

Proceeding

- Sornkaew, N., A. Zhang, R. Chokchaisiri, X. Chen, K. Wongkrajang, and A. Suksamrarn. Diarylheptanoids of Curcuma comosa from Prachin Buri. PACCON2013. 832-835.

POSTERS

- Sornkaew, N.; Chokchaisiri. R, Wongkrajang. K, and Suksamrarn A. Polar diarylheptanoids from the rhizomes of Curcuma comosa. 2010. The 36th Congress on Science and Technology of Thailand (STT 36), 26-28 Oct.

- Sornkaew, N., Zhang. A, Chokchaisiri. R, Chen. X, Wongkrajang. K and Suksamrarn A. 2013. Diarylheptanoids of Curcuma comosa from Prachin Buri. 2013. Pure and Applied  Chemistry International Conference (PACCON 2013), Bangsaen Beach, 23-25 Jan.

- Sornkaew, N. Chokchaisiri. R, and Suksamrarn, A., Diarylheptanoid Constituents of Curcuma comosa from Different Parts of Thailand. 2013. 8th International Congress for Innovation in Chemistry (PERCH-CIC Congress VIII), Jomtien Palm Beach Hotel &  Resort, Pattaya, 5-8 May.

- Sornkaew, N. C. Pholpramool, G. Chaturapanich, Chokchaisiri. R, Wang. W, Zhang. G, and Suksamrarn, A. Diarylheptanoids of Curcuma comosa from Sakon Nakhon Induced Increases in Femoral Arterial Blood Flow in Ovariectomised Rats. 2016. 9th International Congress for Innovation in Chemistry (PERCH-CIC Congress VIIII),  Jomtien Palm Beach Hotel &  Resort, Pattaya, 26-29 Jun.

- Santiwat, T. Sornkaew, N. Sukwattanasinitt, M. Niamnont, N. A highly sensitive and selective of novel triphenylamine-pyrenyl salicylic acid fluorophore for detection of picomolar amounts of Cu2+ ion in aqueous media. 2021.  TRF Research Team Promotion Grant Symposium Functional dyes as optical chemosensors and photocatalysts,  Kantary Hotel Nakhon Ratchasima. 17-18 Dec.

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SCHOLARSHIP

- 2010-2013, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission.

- 2014-2019, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission.

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