ABSTRACT: This study investigated how leadership, organizational culture, work ethics, and conflicts influences work satisfaction and job performance in Thailand’s Public Universities. The study was considered vital due to the importance of quality of education in Thailand Public universities, which is resultant from work satisfaction and job performance of the staff. As a result, several variables, leadership, organizational culture, work ethics, and conflicts were analysed to find their effects on work satisfaction and job performance. The study adopted a quantitative study using primary data. The data was collected from 390 employees working in Thailand public universities. The data analysis was evaluated using multiple regression analysis to evaluate the research hypothesis. The findings of the study indicated that leadership has a significant and positive effect on work satisfaction and job performance. Work ethics positively and significantly influences work satisfaction and job performance. Conflicts was found to have a significant influence on the work satisfaction and job performance. The study also indicated that work satisfaction has a positive and significant influence on job performance. The study recommended that need have effective leadership as a mechanism of fostering better work satisfaction and hob performance, using task-oriented behaviour, relations-oriented behaviour, and change-oriented behaviour. Public universities in Thailand should also engage in actives that develop constructive work ethics.